Antibiotic use in Dutch hospitals 1991–1996

摘要: The use of antibiotics in Dutch hospitals between 1991 and 1996 was investigated. A total 54 responded to the enquiry, representing over 70% all hospital beds Netherlands. hospitals, expressed as defined daily doses (DDD) per hundred bed days, gradually increased from 37.2 DDD 100 days 42.5 1996. antibiotic that showed largest increase co-amoxiclav. Its more than three-fold 3.93 12.5 co-amoxiclav exceeded consumption. cephalosporins remained fairly constant during study period, but there were changes relative different cephalosporin groups. earlier decreased, whereas recently developed Ciprofloxacin norfloxacin most commonly used fluoroquinolones throughout period. ofloxacin significantly 1996, approaching levels ciprofloxacin norfloxacin. There may be complex reasons for increases, which need further analysis, they mirror those few data available elsewhere world. Possible explanations include intensive treatment expedite patient discharges, sicker patients with serious infections resistant organisms.