Hydrogen‐Borrowing and Interrupted‐Hydrogen‐Borrowing Reactions of Ketones and Methanol Catalyzed by Iridium
作者： Di Shen , Darren L. Poole , Camilla C. Shotton , Anne F. Kornahrens , Mark P. Healy
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摘要: Reported herein is the use of catalytic [{Ir(cod)Cl}2] to facilitate hydrogen-borrowing reactions ketone enolates with methanol at 65 °C. An oxygen atmosphere accelerates process, and when combined a bulky monodentate phosphine ligand, interrupts cycle by preventing enone reduction. Subsequent addition pro-nucleophiles reaction mixture allowed one-pot methylenation/conjugate protocol be developed, which greatly expands range products that can made this methodology.
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