Polymorphisms in immunoregulatory genes and the risk of histologic chorioamnionitis in Caucasoid women: a case control study
作者： Margaret F Annells , Prue H Hart , Charles G Mullighan , Susan L Heatley , Jeffrey S Robinson
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摘要: Chorioamnionitis is a common underlying cause of preterm birth (PTB). It hypothesised that polymorphisms in immunoregulatory genes influence the host response to infection and subsequent birth. The relationship between histologic chorioamnionitis 22 single nucleotide 11 was examined case-control study. Placentas 181 Caucasoid women with spontaneous PTB prior 35 weeks were for chorioamnionitis. Polymorphisms IL1A, IL1B, IL1RN, IL1R1, tumour necrosis factor (TNF), IL4, IL6, IL10, transforming growth beta-1 (TGFB1), Fas (TNFRSF6), mannose-binding lectin (MBL2) genotyped by polymerase chain reaction sequence specific primers. Multivariable logistic regression including demographic genetic variables Kaplan-Meier survival analyses genotype frequencies pregnancy outcome performed. Sixty-nine (34%) had evidence acute Carriage IL10-1082A/-819T/592A (ATA) haplotype [Multivariable Odds ratio (MOR) 1.9, P = 0.05] MBL2 codon 54Asp allele (MOR 2.0, 0.04), positively associated chorioamnionitis, while TNFRSF6-1377A/-670G (AG) 0.4, 0.03) homozygosity TGFB1-800G/509T (GT) 0.2, 0.04) negatively associated. These findings demonstrate MBL2, TNFRSF6 TGFB1 may susceptibility
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Roberto Romero, Dan T. Brody, Enrique Oyarzun, Moshe Mazor, Ying King Wu, John C. Hobbins, Scott K. Durum, Infection and labor. III. Interleukin-1: a signal for the onset of parturition. American Journal of Obstetrics and Gynecology. ,vol. 160, pp. 1117- 1123 ,(1989) , 10.1016/0002-9378(89)90172-5
E Mueller-Heubach, S S Schwarz, D N Rubinstein, Histologic chorioamnionitis and preterm delivery in different patient populations. Obstetrics & Gynecology. ,vol. 75, pp. 622- 626 ,(1990)
Lon R Cardon, John I Bell, None, Association study designs for complex diseases Nature Reviews Genetics. ,vol. 2, pp. 91- 99 ,(2001) , 10.1038/35052543
J. A. L. Kurtzhals, L. P. Ryder, S. Thiel, P. Garred, L. U. Lamm, A. Svejgaard, H. O. Madsen, Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein. Journal of Immunology. ,vol. 155, pp. 3013- 3020 ,(1995)
C G Mullighan, H M Chapel, K I Welsh, G C Fanning, TNF and lymphotoxin-alpha polymorphisms associated with common variable immunodeficiency: role in the pathogenesis of granulomatous disease. Journal of Immunology. ,vol. 159, pp. 6236- 6241 ,(1997)
Mehmet R. Genç, Stefan Gerber, Mirjana Nesin, Steven S. Witkin, Polymorphism in the interleukin-1 gene complex and spontaneous preterm delivery. American Journal of Obstetrics and Gynecology. ,vol. 187, pp. 157- 163 ,(2002) , 10.1067/MOB.2002.122407
James F. Curtin, Thomas G. Cotter, Live and let die: regulatory mechanisms in Fas-mediated apoptosis Cellular Signalling. ,vol. 15, pp. 983- 992 ,(2003) , 10.1016/S0898-6568(03)00093-7
Y-M.D. Lo, P. Patel, C.R. Newton, A.F. Markham, K.A. Fleming, J.S. Wainscoat, Direct haplotype determination by double ARMS: specificity, sensitivity and genetic applications Nucleic Acids Research. ,vol. 19, pp. 3561- 3567 ,(1991) , 10.1093/NAR/19.13.3561
Monica M Lahra, Heather E Jeffery, A fetal response to chorioamnionitis is associated with early survival after preterm birth. American Journal of Obstetrics and Gynecology. ,vol. 190, pp. 147- 151 ,(2004) , 10.1016/J.AJOG.2003.07.012
Roberto Romero, Rogelio Gonzalez, Waldo Sepulveda, Francisco Brandt, Marcelo Ramirez, Yoram Sorokin, Moshe Mazor, Marjorie C. Treadwell, David B. Cotton, Infection and labor. VIII. Microbial invasion of the amniotic cavity in patients with suspected cervical incompetence: prevalence and clinical significance. American Journal of Obstetrics and Gynecology. ,vol. 167, pp. 1086- 1091 ,(1992) , 10.1016/S0002-9378(12)80043-3