Devices and methods for reducing matrix effects
作者： David C. Jones
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摘要: Devices and methods are provided for reducing matrix effects in protein precipitated bioanalytical samples comprising: a support, sorbent associated with the support capable of binding interfering agents present sample, wherein device further comprises filtering means removing particles. The is size exclusion filter or polymeric inorganic monolith having maximum pore less than equal to diameter particles be removed from can integral sorbent. characterized by sufficient selectivity between analytes interest provide retention while providing elution (e.g., reversed phase polar modified phase). Typical devices incorporating these features include luer syringe filters, individual cartridges, multiwell plates, pipette tips, inline columns multiple single use.
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