Experimental hypersensitivity pneumonitis. Effect of CD4 cell depletion.
作者： M Schuyler , K Gott , B Edwards , K J Nikula
DOI: 10.1164/AJRCCM.149.5.7909706
关键词:
摘要: We previously demonstrated that Thy1.2+, CD4+, Ia-T cells are responsible for transfer of adoptive murine experimental hypersensitivity pneumonitis (adoptive EHP). To characterize the development pulmonary inflammation in recipient animals, we depleted recipients CD4+ using monoclonal antibody GK1.5 before administration Micropolyspora faeni-sensitized cultured C3H/HeJ spleen (SC) and intratracheal (i.t.) challenge with M. faeni. also used same depletion technique to determine contribution these response i.t. faeni animals did not receive (direct The nature extent inflammatory changes were assayed either 4 days after EHP or 2 direct EHP. Cultured SC could naive those treated an irrelevant antibody. Depletion cells...
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