Minor depressive disorder and subsyndromal depressive symptoms: functional impairment and response to treatment

摘要: Abstract Background: This study quantifies functional impairment and depressive symptomatology in patients with minor disorder (MinD) subsyndromal (SSD) before after 8 weeks of treatment fluvoxamine. Study were compared contrasted archival data from a sample the general population measured by Medical Outcome Survey Short Form 36. Method: Fifteen MinD 15 SSD identified primary care clinics, referrals newspaper advertisements. Patients signed informed consent offered open label fluvoxamine 25–100 mg/day. seen biweekly measures gathered systematically. Results: associated dysfunction disability when to normative population. Eight week was substantial decrease normalization psychosocial functioning. Conclusion: is first quantify severity clinical SSD, demonstrate that selective serotonin reuptake inhibitor decreases improves Placebo-controlled double-blind confirmation these preliminary observations seems warranted.