Enhancement of iron-catalyzed lipid peroxidation by acidosis in brain homogenate: Comparative effect of diphenyl diselenide and ebselen

摘要: Iron is more soluble at lower pH values; therefore we hypothesized that decreasing the environmental would lead to increased iron-mediated lipid peroxidation. Diphenyl diselenide and ebselen are potential candidates as neuroprotective agent, particularly in situations involving overproduction of free radicals cellular fall. The aim present study was (a) investigate relationship between peroxidation acidosis brain homogenate (b) test influence on antioxidant properties diphenyl ebselen. For purpose rat incubated different ranging from physiological acidic values extent measured. Thiobarbituric acid-reactive species (TBARS) production significantly when (5.4-6.8) medium both absence presence Fe (II) compared with (7.4). These data indicate processes, mediated by iron, enhanced extracellular pH. iron mobilized may come reserves where it weakly bound. protected TBARS all studied while offered only a small statistically non-significant protection. However, calculated IC(50) for inhibition indicated did not change anti-oxidant activities tested compounds. This provides in-vitro evidence induced oxidative stress action diselenide.