Synthesis and Antibacterial Activity of Thiophenes
作者： Wedad M. Al-Adiwish , W. A. Yaacob , D. Adan , I. Nazlina
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摘要: 2-[Bis(methylthio)methylene]propanedinitrile 1a reacted in one-pot successively with piperidine, sodium sulfide, chloroacetonitrile, and potassium carbonate to afford 3-amino-5-(1-piperidinyl)-2,4-thiophenedicarbonitrile 2a. Similar reaction using the last three reagents ethyl 2-cyano-3,3-bis(methylthio)acrylate 1b produced 4-amino-5-cyano-2-(methylthio)thiophene-3-carboxylate 2b. The synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR, mass spectral data. Antibacterial activities of are also reported.
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researchgate.net 参考文章(11)
Charles R. Petrie, Howard B. Cottam, Patricia A. McKernan, Roland K. Robins, Ganapathi R. Revankar, Synthesis and biological activity of 6-azacadeguomycin and certain 3,4,6-trisubstituted pyrazolo[3,4-d]pyrimidine ribonucleosides. Journal of Medicinal Chemistry. ,vol. 28, pp. 1010- 1016 ,(1985) , 10.1021/JM00146A007
David Thomae, Enrico Perspicace, Zhanjie Xu, Dorothée Henryon, Serge Schneider, Stéphanie Hesse, Gilbert Kirsch, Pierre Seck, One-pot synthesis of new 2,4,5-trisubstituted 1,3-thiazoles and 1,3-selenazoles Tetrahedron. ,vol. 65, pp. 2982- 2988 ,(2009) , 10.1016/J.TET.2009.01.104
Geoffroy Sommen, Alain Comel, Gilbert Kirsch, An improved method for the synthesis of aminothiophenes precursors of thieno[2,3-b]pyrrole Tetrahedron Letters. ,vol. 43, pp. 257- 259 ,(2002) , 10.1016/S0040-4039(01)02130-X
Magda N. Nasr, Magdy M. Gineinah, Pyrido [2, 3‐d]pyrimidines and Pyrimido[5′, 4′:5, 6]pyrido[2, 3‐d]pyrimidines as New Antiviral Agents: Synthesis and Biological Activity Archiv Der Pharmazie. ,vol. 335, pp. 289- 295 ,(2002) , 10.1002/1521-4184(200208)335:6<289::AID-ARDP289>3.0.CO;2-Z
Pedro J. Campos, Elena Añón, M.Carmen Malo, Miguel A. Rodríguez, A versatile synthesis of pyrrolo-, furo- and thienopyridines via photocyclization of 3-amino-2-alkene imines in an acid medium Tetrahedron. ,vol. 55, pp. 14079- 14088 ,(1999) , 10.1016/S0040-4020(99)00874-1
Geoffroy Sommen, Alain Comel, Gilbert Kirsch, Preparation of thieno[2,3-b]pyrroles starting from ketene-N,S-acetals Tetrahedron. ,vol. 59, pp. 1557- 1564 ,(2003) , 10.1016/S0040-4020(03)00054-1
A. W. Bauer, W. M. M. Kirby, J. C. Sherris, M. Turck, Antibiotic Susceptibility Testing by a Standardized Single Disk Method American Journal of Clinical Pathology. ,vol. 45, pp. 493- 496 ,(1966) , 10.1093/AJCP/45.4_TS.493
Ahmed El-Saghier, A Simple Synthesis of Some New Thienopyridine and Thienopyrimidine Derivatives Molecules. ,vol. 7, pp. 756- 766 ,(2002) , 10.3390/71000756
Bothaina Abdel-Fattah, Manal M. Kandeel, Maha Abdel-Hakeem, Zeinab M. Fahmy, Synthesis of Certain Fused Thienopyrimidines of Biological Interest Journal of The Chinese Chemical Society. ,vol. 53, pp. 403- 412 ,(2006) , 10.1002/JCCS.200600051
Khaled M. Kreddan, Mahmoud F. Farhat, Hind Bin Hussien, Fathy S. Matough, Somaia O. El-Tier, Nabil A. Saleh, Ahmed M. M. El-Saghier, Synthesis and Biological Evaluation of Some New Thienopyridine and Thienopyrimidine Derivatives Deanship of Research and Graduate Studies , Yarmouk University, Irbid , Jordan. ,(1983)