Multiscale approaches to protein-mediated interactions between membranes—relating microscopic and macroscopic dynamics in radially growing adhesions

摘要: Macromolecular complexation leading to coupling of two or more cellular membranes is a crucial step in number biological functions the cell. While other mechanisms may also play role, adhesion always involves fluctuations deformable membranes, diffusion proteins and molecular binding unbinding. Because these stochastic processes couple over multitude time length scales, theoretical modeling membrane has been major challenge. Here we present an effective Monte Carlo scheme within which effects are integrated into local rates for recognition. The latter approach enables us simulate nucleation growth domains system size cell tens seconds without loss accuracy, as shown by comparison 106 times expensive Langevin simulations. To perform this validation, was augmented explicitly, together with reaction kinetics dynamics. We use gain deeper insight experimentally observed radial micron sized domains, connect rate domain growing underlying microscopic events. thus demonstrate that our technique yields detailed information about protein transport fundamental toward understanding even complex interactions context.