A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead.
作者： Tomasz Wilanowski , Annabel Tuckfield , Loretta Cerruti , Sinead O'Connell , Robert Saint
DOI: 10.1016/S0925-4773(02)00046-1
关键词:
摘要: The Drosophila transcription factor Grainyhead regulates several key developmental processes. Three mammalian genes, CP2, LBP-1a and LBP-9 have been previously identified as homologues of grainyhead. We now report the cloning two new genes (Mammalian grainyhead (MGR) Brother-of-MGR (BOM)) one gene (dCP2) that rewrite phylogeny this family. demonstrate MGR BOM are more closely related to grh, whereas descendants dCP2 gene. shares greatest sequence homology with is expressed in tissue-restricted patterns comparable grh binds transactivates promoter human Engrailed-1 gene, homologue target engrailed. This functional conservation indicates members family play important roles.
elsevier.com
sci-hub.se 参考文章(49)
J. A. Garcia, F. K. Wu, R. Mitsuyasu, R. B. Gaynor, Interactions of cellular proteins involved in the transcriptional regulation of the human immunodeficiency virus. The EMBO Journal. ,vol. 6, pp. 3761- 3770 ,(1987) , 10.1002/J.1460-2075.1987.TB02711.X
M. B. O'Connor, R. Binari, L. A. Perkins, W. Bender, Alternative RNA products from the Ultrabithorax domain of the bithorax complex. The EMBO Journal. ,vol. 7, pp. 435- 445 ,(1988) , 10.1002/J.1460-2075.1988.TB02831.X
S.M. Jane, A.W. Nienhuis, J.M. Cunningham, Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein. The EMBO Journal. ,vol. 14, pp. 97- 105 ,(1995) , 10.1002/J.1460-2075.1995.TB06979.X
A. Busturia, I. Vernos, A. Macias, J. Casanova, G. Morata, Different forms of Ultrabithorax proteins generated by alternative splicing are functionally equivalent. The EMBO Journal. ,vol. 9, pp. 3551- 3555 ,(1990) , 10.1002/J.1460-2075.1990.TB07565.X
F. K. Wu, J. A. Garcia, D. Harrich, R. B. Gaynor, Purification of the human immunodeficiency virus type 1 enhancer and TAR binding proteins EBP-1 and UBP-1. The EMBO Journal. ,vol. 7, pp. 2117- 2130 ,(1988) , 10.1002/J.1460-2075.1988.TB03051.X
J B Yoon, G Li, R G Roeder, Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro. Molecular and Cellular Biology. ,vol. 14, pp. 1776- 1785 ,(1994) , 10.1128/MCB.14.3.1776
S J Bray, F C Kafatos, Developmental function of Elf-1: an essential transcription factor during embryogenesis in Drosophila. Genes & Development. ,vol. 5, pp. 1672- 1683 ,(1991) , 10.1101/GAD.5.9.1672
K Kornfeld, R B Saint, P A Beachy, P J Harte, D A Peattie, D S Hogness, Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila. Genes & Development. ,vol. 3, pp. 243- 258 ,(1989) , 10.1101/GAD.3.2.243
A.Javier López, Developmental Role of Transcription Factor Isoforms Generated by Alternative Splicing Developmental Biology. ,vol. 172, pp. 396- 411 ,(1995) , 10.1006/DBIO.1995.8050
L. D. Attardi, D. Von Seggern, R. Tjian, Ectopic expression of wild-type or a dominant-negative mutant of transcription factor NTF-1 disrupts normal Drosophila development. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 10563- 10567 ,(1993) , 10.1073/PNAS.90.22.10563