Genetic Deficiency of Chemokine Receptor CCR5 Is a Strong Risk Factor for Symptomatic West Nile Virus Infection: A Meta-Analysis of 4 Cohorts in the US Epidemic
作者： Jean K. Lim , Christine Y. Louie , Carol Glaser , Cynthia Jean , Bernard Johnson
DOI: 10.1086/524691
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摘要: West Nile virus (WNV) causes disease in approximately 20% of infected humans. We previously reported that homozygosity for CCR5Delta32, a nonfunctional variant chemokine receptor CCR5, is markedly increased among symptomatic WNV-seropositive patients from Arizona and Colorado. To confirm this, we analyzed cohorts California Illinois. An increase CCR5-deficient subjects was found both (for California, odds ratio [OR], 4.2 [95% confidence interval {CI}, 1.5-11.9] [P= .004]; Illinois, OR, 3.1 CI, 0.9-11.2] .06]). A meta-analysis all 4 showed an OR (95% 2.1-8.3 .0001]). Thus, CCR5 deficiency strong consistent risk factor WNV infection the United States.
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