Drug Resistance Mechanisms to Gamma-secretase Inhibitors in Human Colon Cancer Cells

Takashi Akiyoshi, Masafumi Nakamura, Kosuke Yanai, Shuntaro Nagai, Junji Wada, Kenichiro Koga, Hiroshi Nakashima, Norihiro Sato, Masao Tanaka, Mitsuo Katano, γ-Secretase Inhibitors Enhance Taxane-Induced Mitotic Arrest and Apoptosis in Colon Cancer Cells Gastroenterology. ,vol. 134, pp. 131- 144 ,(2008) , 10.1053/J.GASTRO.2007.10.008

K. M. Neely, K. N. Green, F. M. LaFerla, Presenilin Is Necessary for Efficient Proteolysis through the Autophagy–Lysosome System in a γ-Secretase-Independent Manner The Journal of Neuroscience. ,vol. 31, pp. 2781- 2791 ,(2011) , 10.1523/JNEUROSCI.5156-10.2010

A Saraste, Morphologic and biochemical hallmarks of apoptosis Cardiovascular Research. ,vol. 45, pp. 528- 537 ,(2000) , 10.1016/S0008-6363(99)00384-3

J F R Kerr, A H Wyllie, A R Currie, Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. British Journal of Cancer. ,vol. 26, pp. 239- 257 ,(1972) , 10.1038/BJC.1972.33

Mingyi Wang, Jian Wang, Lin Wang, Liying Wu, Xiaoyan Xin, Notch1 expression correlates with tumor differentiation status in ovarian carcinoma Medical Oncology. ,vol. 27, pp. 1329- 1335 ,(2010) , 10.1007/S12032-009-9384-8

Pierre-Emmanuel Rautou, Abdellah Mansouri, Didier Lebrec, François Durand, Dominique Valla, Richard Moreau, Autophagy in liver diseases Journal of Hepatology. ,vol. 53, pp. 1123- 1134 ,(2010) , 10.1016/J.JHEP.2010.07.006

CHRISTOPHER S. POTTEN, CATHERINE BOOTH, D. MARK PRITCHARD, The intestinal epithelial stem cell: the mucosal governor International Journal of Experimental Pathology. ,vol. 78, pp. 219- 243 ,(2003) , 10.1046/J.1365-2613.1997.280362.X

Ruben Plentz, Ji–Sun Park, Andrew D. Rhim, Daniel Abravanel, Aram F. Hezel, Sreenath V. Sharma, Sushma Gurumurthy, Vikram Deshpande, Candia Kenific, Jeffrey Settleman, Pradip K. Majumder, Ben Z. Stanger, Nabeel Bardeesy, Inhibition of γ-Secretase Activity Inhibits Tumor Progression in a Mouse Model of Pancreatic Ductal Adenocarcinoma Gastroenterology. ,vol. 136, pp. 1741- 1749 ,(2009) , 10.1053/J.GASTRO.2009.01.008

Jacqueline L. Avila, Joseph L. Kissil, Notch signaling in pancreatic cancer: oncogene or tumor suppressor? Trends in Molecular Medicine. ,vol. 19, pp. 320- 327 ,(2013) , 10.1016/J.MOLMED.2013.03.003

J. V. McCarthy, C. Twomey, P. Wujek, Presenilin-dependent regulated intramembrane proteolysis and γ-secretase activity Cellular and Molecular Life Sciences. ,vol. 66, pp. 1534- 1555 ,(2009) , 10.1007/S00018-009-8435-9