Decreased activation of cingulo-frontal-parietal cognitive/attention network during an attention-demanding task in patients with chronic low back pain.

摘要: Attention deficits have been repeatedly reported via neuropsychological assessment in previous literature patients with chronic low back pain (CLBP). However, there are few functional neuroimaging studies of CLBP during attention processing, and the exact underlying neural mechanisms yet to be elucidated. We used magnetic resonance imaging (fMRI) measure function cingulo-frontal-parietal (CFP) cognitive/attention network while performing a multi-source interference task (MSIT) CLBP. Thirty-six 36 healthy controls were included this study. The fMRI data analyzed FSL-FEAT software. Our results indicated that showed significantly less activation CFP including right dorsolateral prefrontal cortex, dorsal anterior cingulate bilateral superior parietal cortex attention-demanding (MSITinterference > MSITcontrol) trials compared controls. A significant negative correlation was found between scores visual analog scale for MSIT study provides vivo evidence abnormal condition CLBP, which might reflect partly an adaptation/maladaptation brain states.