COMPOSITION COMPRISING CITRATE AND CARNITINE ABLE TO ACTIVATE THE PRODUCTION OF THE PROTEIN KLOTHO
作者： Castellano Giuseppe , Sallustio Fabio , Stasi Alessandra , Franzin Rossana , Arduini Arduino
DOI:
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摘要: A composition comprising citrate and carnitine which activates the production of protein Klotho by renal tubule cells protecting them, thus reducing oxidative stress conditions thereof, can be used for conservation, perfusion reperfusion organs organ transplants is disclosed. Furthermore, in liquid dietary/nutraceutical formulation nephrotoxicity induced iodinated contrast means, antibiotics, NSAIDs 10or agents that induce stress.
lens.org 参考文章(55)
H. Phillip Koeffler, Lilach Abramovitch, Tamar Rubinek, Ido Wolf, Bella Kaufman, Klotho protein and related compounds for the treatment and diagnosis of cancer ,(2008)
Linda Maureen O'bryan, Matthew Douglas Breyer, Rosamund Carol Smith, Therapeutic uses of soluble alpha-klotho ,(2010)
Kenneth Lim, Arnoud Groen, Guerman Molostvov, Tzongshi Lu, Kathryn S. Lilley, David Snead, Sean James, Ian B. Wilkinson, Stephen Ting, Li-Li Hsiao, Thomas F. Hiemstra, Daniel Zehnder, α-Klotho Expression in Human Tissues. The Journal of Clinical Endocrinology and Metabolism. ,vol. 100, ,(2015) , 10.1210/JC.2015-1800
Shinji Ito, Toshihiko Fujimori, Akiko Furuya, Junko Satoh, Yoko Nabeshima, Yo-ichi Nabeshima, Impaired negative feedback suppression of bile acid synthesis in mice lacking βKlotho Journal of Clinical Investigation. ,vol. 115, pp. 2202- 2208 ,(2005) , 10.1172/JCI23076
Kenneth Lim, Tzong-Shi Lu, Guerman Molostvov, Christina Lee, F.T. Lam, Daniel Zehnder, Li-Li Hsiao, Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23 Circulation. ,vol. 125, pp. 2243- 2255 ,(2012) , 10.1161/CIRCULATIONAHA.111.053405
Jian Xie, Seung-Kuy Cha, Sung-Wan An, Makoto Kuro-o, Lutz Birnbaumer, Chou-Long Huang, Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart Nature Communications. ,vol. 3, pp. 1238- 1238 ,(2012) , 10.1038/NCOMMS2240
Cristina Zanchi, Monica Locatelli, Ariela Benigni, Daniela Corna, Susanna Tomasoni, Daniela Rottoli, Flavio Gaspari, Giuseppe Remuzzi, Carlamaria Zoja, None, Renal Expression of FGF23 in Progressive Renal Disease of Diabetes and the Effect of Ace Inhibitor PLoS ONE. ,vol. 8, pp. e70775- 8 ,(2013) , 10.1371/JOURNAL.PONE.0070775
Eric Seibert, Gunnar H. Heine, Christof Ulrich, Sarah Seiler, Hans Köhler, Matthias Girndt, Influence of cholecalciferol supplementation in hemodialysis patients on monocyte subsets: a randomized, double-blind, placebo-controlled clinical trial. Nephron Clinical Practice. ,vol. 123, pp. 209- 219 ,(2013) , 10.1159/000354717
Javier Donate-Correa, Carmen Mora-Fernández, Rafael Martínez-Sanz, Mercedes Muros-de-Fuentes, Horacio Pérez, Beatriz Meneses-Pérez, Violeta Cazaña-Pérez, Juan F. Navarro-González, Expression of FGF23/KLOTHO system in human vascular tissue. International Journal of Cardiology. ,vol. 165, pp. 179- 183 ,(2013) , 10.1016/J.IJCARD.2011.08.850
Yuji Yamazaki, Akihiro Imura, Itaru Urakawa, Takashi Shimada, Junko Murakami, Yukiko Aono, Hisashi Hasegawa, Takeyoshi Yamashita, Kimihiko Nakatani, Yoshihiko Saito, Nozomi Okamoto, Norio Kurumatani, Noriyuki Namba, Taichi Kitaoka, Keiichi Ozono, Tomoyuki Sakai, Hiroshi Hataya, Shoji Ichikawa, Erik A. Imel, Michael J. Econs, Yo-ichi Nabeshima, Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects. Biochemical and Biophysical Research Communications. ,vol. 398, pp. 513- 518 ,(2010) , 10.1016/J.BBRC.2010.06.110