Impact of continuous positive airway pressure treatment on right ventricle performance in patients with obstructive sleep apnoea, assessed by three-dimensional echocardiography

摘要: Abstract Background Obstructive sleep apnoea (OSA) is a predictor of right ventricle (RV) impairment. However, there scant information on the effect OSA treatment RV performance. We sought to evaluate impact with continuous positive airway pressure (CPAP) device volume and function, as well variables related pulmonary vascular haemodynamics. Methods Fifty-six patients 50 controls were studied. All individuals underwent three-dimensional echocardiogram (3DE) estimate volumes, resistance, tricuspid regurgitation velocity. A total 30 apnoea-hypopnoea index greater than 20 randomly selected receive placebo ( n =15) or effective CPAP for 24weeks. They 3DE examination three different occasions: at baseline, after 12weeks, 24weeks placebo. Results Higher resistance (2.1 Wood's±0.5 vs. 1.8 Wood's±0.4), larger end-diastolic (52.2mL/m 2 ±7.3 49.9mL/m ±6.0), end-systolic (18.7mL/m ±4.3 15.4mL/m ±3.6), lower ejection fraction (64.3%±6.8 68.4%±5.9) observed in group compared non-OSA P ±4.5 16mL/m ±2.1); (C) increase (63.0%±7.2 70.8%±0.9) Conclusion Twenty-four-week improved performance but did not change structural variables.