Population Diversity and Collective Interactions during Influenza Virus Infection.

摘要: ABSTRACT Influenza A virus (IAV) continues to pose an enormous and unpredictable global public health threat, largely due the continual evolution of escape from preexisting immunity potential for zoonotic emergence. Understanding how unique genetic makeup structure IAV populations influences their transmission is essential developing more-effective vaccines, therapeutics, surveillance capabilities. Owing mutation-prone replicase genome organization, exhibit amounts diversity both in terms sequence functional gene content. Here, I review what currently known about genomic present within this may shape replicative evolutionary dynamics these viruses.