Association between intake of sweetened beverages with all-cause and cause-specific mortality: a systematic review and meta-analysis.

摘要: BACKGROUND Conclusions remain controversial between the consumption of sugar and artificially sweetened beverages (SSBs ASBs) mortality. METHODS We systematically searched PubMed, Embase, Cochrane Library Web Science databases from their inception date to 1st January 2020, prospective cohort studies researching mortality risk SSBs or ASBs were included. Random effects meta-analyses dose-response analyses performed measure association. Subgroup sensitivity further explore source heterogeneity. Publication bias was assessed by Funnel plots Egger's regression test. RESULTS Across all 15 cohorts, 1211 470 participants High SSB associated with a higher all-cause (hazard ratio [HR], 1.12; 95% confidence interval [CI], 1.06-1.19, P < 0.001; cardiovascular disease [CVD] [HR 1.20, CI, 1.05-1.38, P < 0.001]), high showed similar result (HR 1.12, 1.04-1.21, P = 0.001 for HR 1.23, 1.00-1.50, P = 0.049 CVD mortality), both linear relationship. CONCLUSIONS significant associations This information may provide ideas decreasing global burden diseases reducing beverage intake.