The Relationship between the Serum Level of Selenium and Cervical Intraepithelial Neoplasia: A Comparative Study in a Population of Nigerian Women

摘要: Objective: To determine the relationship between serum level of selenium and cervical intraepithelial neoplasia (CIN). Methods: A case controlled study that compared in 45 women with CIN (cases) to (age matched controls) normal cytology. Socio-demographic data information on known risk factors for cancer among sample was both groups using inferential statistics. Results: There no significant difference mean values cases controls [p- 0.076, 95% CI (-15.08 – 0.76)]. However, subgroup analysis showed a statistically patients cytology, I, II III (p= 0.021). In addition, there also cytology (p value = 0.016) inverse linear trend 0.025). Conclusion: With increasing severity CIN, reduction observed. This reducing selenium, surrogate marker increased oxidative stress, may be important factor development persistent HPV infection particular high grade lesions. observation requires further research.