Environmental enrichment attenuates hippocampal neuroinflammation and improves cognitive function during influenza infection

作者: Heidi A. Jurgens , Rodney W. Johnson

DOI: 10.1016/J.BBI.2012.05.015

关键词:

摘要: Recent findings from our lab have shown that peripheral infection of adult mice with influenza A/PR/8/34 (H1N1) virus induces a neuroinflammatory response is paralleled by loss neurotrophic and glial regulatory factors in the hippocampus, deficits cognitive function. Environmental enrichment has been to exert beneficial effects on brain behavior many central nervous system (CNS) disorders, but its therapeutic potential during viral remains unknown. Therefore, objective present study was determine if long-term continuous exposure environmental could prevent and/or attenuate negative hippocampus spatial cognition. Mice were housed enriched or standard conditions for 4 months, continued live their respective environments throughout infection. Cognitive function assessed reversal learning version Morris water maze, changes hippocampal expression proinflammatory cytokines (IL-1β, IL-6, TNF-α, IFN-α), (BDNF, NGF), immunomodulatory (CD200, CX3CL1) determined. We found reduced neuroinflammation helped influenza-induced reduction CD200. These improved performance infected when compared housing conditions. Collectively, these data are first demonstrate positive impact cognition infection, suggest enhanced modulation neuroimmune may underlie effects.

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