Microdosimetric calculations by simulating monoenergetic electrons in voxel models of human normal individual cells

摘要: Abstract This work proposes two kinds of voxel model human normal individual cells, and the Monte Carlo software GATE is used to describe analyze effects some factors on microdosimetric quantity--specific energy, such as shape, volume physical models for interaction. In this paper, “Livermore” “Penelope”, low energy electromagnetic in code Geant4 adopted GATE, are estimate specific energies their distribution a lung epithelial cell (BEAS-2B), renal (293T) size-like simple ellipsoids (hereinafter referred “simple geometry”) respectively. According irradiation conditions radiobiology, four geometries, source isotropically irradiated within cell, axially outside (x-axis positive z-axis negative) surface covered with polypropylene film external monoenergetic electrons beams from 50 keV 1 MeV simulated. The results show that influence phantom 27.35% smaller than ellipsoid. BEAS-2B shows large differences between geometry both cytoplasm nucleus under condition irradiation. For 293T even if shape relatively regular, there deviation certain conditions, maximum 17.78%, while minimum 1.19%. These statistical indicate position can have impact demonstrate terms exploring mechanism radiation biological effects, real phantoms may be more practical valuable traditional aspect modeling. It expected assessment based establishment relevant databases will play unique role predicting dose target volumes accurately given protection clinical radiotherapy.