Challenge in particle delivery to cells in a microfluidic device

摘要: Micro and nanotechnology can potentially revolutionize drug delivery systems. Novel microfluidic systems have been employed for the cell culture applications by micro nanocarriers. Cells in microchannels are under static dynamic flow perfusion of media that provides nutrition removes waste from cells. This exerts hydrostatic hydrodynamic forces on These considerably affect functions living In this paper, we simulated air, medium, particle transport deposition different angles connection inlet. It was found shear stress induced medium is not so high to damage cells it roughly uniform section (CCS). However, local stresses other parts microchip differ changing The results showed a function size, properties fluid, rate. At lower air rate, both small large particles deposited entrance region none them reached CCS. Once airflow rate increased, drag could overcome diffusion deliver CCS more than 88% 100 nm 98% 200 nm larger with average diameters micrometers reach even at contrast, our findings indicated be delivered liquid flow. Our experimental data confirm microparticles (with 5 20 μm) suspended well-adjusted Consequently, carrier suggested through microchannels. As powerful tool, these numerical simulations provide nearly complete understanding field patterns microchips which significantly trial error experiment tests accordingly save researchers considerable cost time micro/nanocarriers.