Cannabidiol Affects the Bezold-Jarisch Reflex via TRPV1 and 5-HT3 Receptors and Has Peripheral Sympathomimetic Effects in Spontaneously Hypertensive and Normotensive Rats

摘要: Cannabidiol (CBD) is a nonpsychotropic constituent of Cannabis sativa L. It suggested to be useful in hypertension. Under vitro conditions, it activates vanilloid TRPV1 and inhibits serotonin 5-HT3 receptors, i.e., receptors involved the Bezold-Jarisch reflex stimulation. The aim our study was compare cardiovascular effects CBD spontaneously hypertensive (SHR) normotensive Wistar Kyoto (WKY) rats. Experiments were performed on conscious, urethane-anesthetized, pithed In SHR WKY, increased heart rate (HR) systolic blood pressure (SBP) decreased diastolic BP (DBP) manner insensitive adrenalectomy. Propranolol strongly impaired CBD-induced increases HR SBP without affecting decreases DBP. Desipramine also reduced further its anesthetized rats, bolus i.v. injection single doses induced short-lasting HR, SBP, DBP, stronger than WKY prevented by bilateral vagotomy. fall but not diminished receptor antagonist capsazepine almost completely abolished if re-injected after previous administration. elicited agonist phenylbiguanide that evoked capsaicin. conscious did affect parameters. isolated left atria, contractile force. Conclusions: (1) induces likely via (which undergo tachyphylaxis) more markedly WKY; (2) activation receptors; (3) has peripheral sympathomimetic, (4) vasodilatory, (5) negative inotropic effects. above properties should taken under consideration when used for therapeutic purposes.