Chronic migraine—classification, characteristics and treatment

摘要: According to the revised 2nd Edition of International Classification Headache Disorders, primary headaches can be categorized as chronic or episodic; migraine is defined in absence medication overuse, occurring on ≥15 days per month for ≥3 months, which ≥8 must fulfill criteria without aura. Prevalence and incidence data are still uncertain, owing heterogeneous definitions used identify condition population-based studies over past two decades. Chronic severely disabling difficult manage, affected patients experience substantially more-frequent headaches, comorbid pain affective disorders, fewer pain-free intervals, than do those with episodic migraine. Data treatment scarce because most migraine-prevention trials excluded who had month. Despite this lack reliable data, a wealth expert opinion few evidence-based options available managing Trial topiramate botulinum toxin type A, suggests that conventional preventive therapy may also useful. This Review discusses evolution our understanding migraine, including its epidemiology, pathophysiology, clinical characteristics options.