Nonalcoholic fatty liver disease and statins

作者: Konstantinos Tziomalos , Vasilios G. Athyros , Paschalis Paschos , Asterios Karagiannis

DOI: 10.1016/J.METABOL.2015.07.003

关键词:

摘要: Abstract Objective Nonalcoholic fatty liver disease (NAFLD) is the most frequent cause of elevated transaminase levels and affects approximately one third general population. Patients with NAFLD are at increased risk for cardiovascular events, which represent leading death in this We discuss safety efficacy statins Materials/methods reviewed recent literature on patients their effects histology events. Results It appears that can be safely administered to NAFLD, including those ( Conclusions Statins appear safe might also reduce events NAFLD. Ongoing future studies will clarify whether have a role treatment

参考文章(86)
Yumie Takeshita, Toshinari Takamura, Masao Honda, Yuki Kita, Yoh Zen, Ken-ichiro Kato, Hirofumi Misu, Tsuguhito Ota, Mikiko Nakamura, Kazutoshi Yamada, Hajime Sunagozaka, Kuniaki Arai, Tatsuya Yamashita, Eishiro Mizukoshi, Shuichi Kaneko, The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial Diabetologia. ,vol. 57, pp. 878- 890 ,(2014) , 10.1007/S00125-013-3149-9
Jeanne M. Clark, Frederick L. Brancati, Anna Mae Diehl, The prevalence and etiology of elevated aminotransferase levels in the United States. The American Journal of Gastroenterology. ,vol. 98, pp. 960- 967 ,(2003) , 10.1111/J.1572-0241.2003.07486.X
Ki Hoon Han, Seung Woon Rha, Hyun-Jae Kang, Jang-Whan Bae, Byoung-Joo Choi, So-Yeon Choi, Hyeon-Cheol Gwon, Jang-Ho Bae, Bum-Kee Hong, Dong-Hoon Choi, Kyoo-Rok Han, Evaluation of short-term safety and efficacy of HMG-CoA reductase inhibitors in hypercholesterolemic patients with elevated serum alanine transaminase concentrations: PITCH study (PITavastatin versus atorvastatin to evaluate the effect on patients with hypercholesterolemia and mild to moderate hepatic damage) Journal of Clinical Lipidology. ,vol. 6, pp. 340- 351 ,(2012) , 10.1016/J.JACL.2012.01.009
Raj Vuppalanchi, Naga Chalasani, Evegenia Teal, Patients with elevated baseline liver enzymes do not have higher frequency of hepatotoxicity from lovastatin than those with normal baseline liver enzymes. The American Journal of the Medical Sciences. ,vol. 329, pp. 62- 65 ,(2005) , 10.1097/00000441-200502000-00002
Roger K. Schindhelm, Jacqueline M. Dekker, Giel Nijpels, Lex M. Bouter, Coen D.A. Stehouwer, Robert J. Heine, Michaela Diamant, Alanine aminotransferase predicts coronary heart disease events: A 10-year follow-up of the Hoorn Study Atherosclerosis. ,vol. 191, pp. 391- 396 ,(2007) , 10.1016/J.ATHEROSCLEROSIS.2006.04.006
Matti J. Tikkanen, Rana Fayyad, Ole Faergeman, Anders G. Olsson, Chuan-Chuan Wun, Rachel Laskey, John J. Kastelein, Ingar Holme, Terje R. Pedersen, Effect of intensive lipid lowering with atorvastatin on cardiovascular outcomes in coronary heart disease patients with mild-to-moderate baseline elevations in alanine aminotransferase levels International Journal of Cardiology. ,vol. 168, pp. 3846- 3852 ,(2013) , 10.1016/J.IJCARD.2013.06.024
Danitza Pradelli, Davide Soranna, Lorenza Scotti, Antonella Zambon, Alberico Catapano, Giuseppe Mancia, Carlo La Vecchia, Giovanni Corrao, None, Statins and primary liver cancer: a meta-analysis of observational studies. European Journal of Cancer Prevention. ,vol. 22, pp. 229- 234 ,(2013) , 10.1097/CEJ.0B013E328358761A
Vasilios G. Athyros, Konstantinos Tziomalos, Georgios N. Daskalopoulos, Asterios Karagiannis, Dimitri P. Mikhailidis, Statin-based treatment for cardiovascular risk and non-alcoholic fatty liver disease. Killing two birds with one stone? Annals of Medicine. ,vol. 43, pp. 167- 171 ,(2011) , 10.3109/07853890.2011.561363
Austin Nelson, Dawn M. Torres, Ana E. Morgan, Christopher Fincke, Stephen A. Harrison, A Pilot Study Using Simvastatin in the Treatment of Nonalcoholic Steatohepatitis: A Randomized Placebo-controlled Trial Journal of Clinical Gastroenterology. ,vol. 43, pp. 990- 994 ,(2009) , 10.1097/MCG.0B013E31819C392E