How body composition influences hearing status by mid-childhood and mid-life: The Longitudinal Study of Australian Children

摘要: Hearing loss is a disabling condition whose prevalence rises with age. Obesity—a risk factor common to many non-communicable diseases—now appears be implicated. We aimed determine: (1) cross-sectional associations of body composition measures hearing in mid-childhood and mid-life (2) its longitudinal 10-year mass index (BMI) trajectories. Design & Participants: There were 1481 11–12-year-old children 1266 mothers the population-based CheckPoint study nested within Longitudinal Study Australian Children (LSAC). Anthropometry (CheckPoint): BMI, fat/fat-free indices, waist-to-height ratio; LSAC wave 2–6-biennial measured BMI. Audiometry Mean threshold across 1, 2 4 kHz; (threshold > 15 dB HL, better ear). Analysis: Latent class models identifying BMI trajectories; linear/logistic regression quantifying composition/trajectories threshold/loss. Measures adiposity, but not fat-free mass, cross-sectionally associated hearing. Fat predicted (β 0.6, 95% confidence interval (CI) 0.3–0.8, P < 0.001;, odds ratio (OR) 1.2, CI 1.0–1.4, P = 0.05) 0.8, 0.5–1.2, P < 0.001; OR 1.1–1.4, P = 0.003). Concurrent obesity (OR 1.5, 1.1–2.1, P = 0.02) (WHtR) ≥ 0.6 1.6, 1.2–2.3, P = 0.01) maternal hearing, similar attenuated patterns children. In analyses, mothers’, children’s, trajectories for severely obese 3.0, 1.4–6.6, P = 0.01). adiposity decade-long showed small, clear, poor women, emergent by mid-childhood. This suggests that may play role rising global burden loss. Replication mechanistic compositional studies could elucidate possible causal relationships.