Pharmacokinetics and haemodynamic effects of tocainide in patients with acute myocardial infarction complicated by left ventricular failure.

作者: B MacMahon , M Bakshi , P Branagan , JG Kelly , MJ Walsh

DOI: 10.1111/J.1365-2125.1985.TB02666.X

关键词:

摘要: The pharmacokinetics and haemodynamic effects of tocainide, an orally active structural analogue lignocaine, were studied in patients with acute myocardial infarction complicated by left ventricular failure. Fourteen (mean age 65 years) mild failure studied, following a single dose tocainide (250 mg) intravenous infusion, over 30 min. Heart rate, systemic arterial pressure, pulmonary artery pressure cardiac output monitored. Plasma levels estimated gas chromatography. mean plasma level achieved was 2.95 micrograms/ml (15.37 mmol/l). half-life 15.6 h. index reduced 5 min after completion the from 2.24 1 min-1 m-2 (+/- 0.40) to 2.07 0.29) (P less than 0.01). At 90 had returned pre-treatment levels. Small changes seen heart blood but these not statistically significant. significantly altered

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