Genotoxicity of nitrated polycyclic aromatic hydrocarbons and related structures on Escherichia coli PQ37 (SOS chromotest).
作者： V. Mersch-Sundermann , S. Kern , F. Wintermann , E. Eisenstadt
关键词:
摘要: To determine the genotoxicity of nitrated polycyclic aromatic hydrocarbons and related molecules (nPAH) we examined 24 compounds representative nitroanthracenes, nitrofluorenes, nitronaphthalenes, nitropyrenes, nitroquinolines for in Escherichia coli PQ37 (SOS-chromotest). enhance sensitivity tester strain optimize metabolic activation used a modified test protocol S9-mix composition. All chemicals with exception 9-nitroanthracene, 1- 2-nitronaphthalene, 2-methyl-1-nitronaphthalene, 5-, 6-, 8-nitroquinoline induced SOS system E. PQ37. As expected from previously referred mutagenicity studies, highest inducing potencies (SOSIP) were exhibited by dinitropyrenes (SOSIP = 151-416), 4-nitroquinoline-N-oxide 62), 3-nitrofluoranthese 16). Except some nPAHs showed their absence an exogeneous system. The results compared to those reported bacterial these substances Salmonella typhimurium TA98.
sci-hub.se 参考文章(19)
O. GOERLICH, E. TOUATI, M. HOFNUNG, P. QUILLARDET, 8 – SOS Chromotest and the Use of Bacteria for the Detection and Diagnosis of Genotoxic Agents New Trends in Genetic Risk Assessment. pp. 125- 136 ,(1989) , 10.1016/B978-0-12-388176-2.50017-5
Herbert S. Rosenkranz, Robert Mermelstein, Mutagenicity and genotoxicity of nitroarenes Mutation Research/Reviews in Genetic Toxicology. ,vol. 114, pp. 217- 267 ,(1983) , 10.1016/0165-1110(83)90034-9
T. C. Pederson, J-S. Siak, The role of nitroaromatic compounds in the direct-acting mutagenicity of diesel particle extracts. Journal of Applied Toxicology. ,vol. 1, pp. 54- 60 ,(1981) , 10.1002/JAT.2550010203
Robert Mermelstein, Demosthenes K. Kiriazides, Marsha Butler, Elena C. McCoy, Herbert S. Rosenkranz, The extraordinary mutagenicity of nitropyrenes in bacteria. Mutation Research\/genetic Toxicology. ,vol. 89, pp. 187- 196 ,(1981) , 10.1016/0165-1218(81)90236-6
Philippe Quillardet, Maurice Hofnung, The SOS Chromotest, a colorimetric bacterial assay for genotoxins: procedures Mutation Research\/environmental Mutagenesis and Related Subjects. ,vol. 147, pp. 65- 78 ,(1985) , 10.1016/0165-1161(85)90020-2
Elena C. McCoy, E.Joshua Rosenkranz, Herbert S. Rosenkranz, Robert Mermelstein, Nitrated fluorene derivatives are potent frameshift mutagens Mutation Research\/genetic Toxicology. ,vol. 90, pp. 11- 20 ,(1981) , 10.1016/0165-1218(81)90046-X
G Klopman, Structural requirements for the mutagenicity of environmental nitroarenes Mutation Research. ,vol. 126, pp. 227- 238 ,(1984) , 10.1016/0027-5107(84)90001-0
Wilhelm von der Hude, Claudia Behm, Rainer Gürtler, Armin Basler, Evaluation of the SOS chromotest Mutation Research/Environmental Mutagenesis and Related Subjects. ,vol. 203, pp. 81- 94 ,(1988) , 10.1016/0165-1161(88)90023-4
V. Mersch-Sundermann, S. Kevekordes, S. Mochayedi, Sources of variability of the Escherichia coli PQ37 genotoxicity assay (SOS chromotest). Mutation Research\/environmental Mutagenesis and Related Subjects. ,vol. 252, pp. 51- 60 ,(1991) , 10.1016/0165-1161(91)90251-3
Dorothy M. Maron, Bruce N. Ames, REVISED METHODS FOR THE SALMONELLA MUTAGENICITY TEST Mutation Research. ,vol. 113, pp. 173- 215 ,(1983) , 10.1016/0165-1161(83)90010-9