Genetic epidemiology of vitiligo: multilocus recessivity cross-validated.

摘要: Vitiligo is a dermatological disorder characterized by hypopigmentary patches that tend to become progressive over time. There are reports of extensive familial aggregation. A genetic model for this was earlier proposed us. This postulates recessive alleles at multiple unlinked autosomal loci interact epistatically in the pathogenesis vitiligo. The present family study primarily undertaken cross-validate model. Data on 194 families from United States were collected. Each ascertained through an affected proband. Analyses these data reveal approximately 20% probands have least one first-degree relative afflicted with All types relatives show significant risk developing Results segregation and robustness analyses postulated us previously most parsimonious set.