Recombinant human leukocyte interferon produced in bacteria has antiproliferative activity.

作者: M. Evinger , S. Maeda , S. Pestka

DOI: 10.1016/S0021-9258(19)69745-0

关键词:

摘要: Abstract Recombinant human leukocyte interferon synthesized by Escherichia coli possesses antiproliferative activity in addition to antiviral activity. When the ability inhibit multiplication of lymphoblastoid Daudi cells was examined, growth-inhibitory capacity recombinant equivalent that exhibited crude or homogeneous gamma 2 species cells.

参考文章(7)
M. Rubinstein, S. Rubinstein, P. C. Familletti, R. S. Miller, A. A. Waldman, S. Pestka, Human leukocyte interferon: production, purification to homogeneity, and initial characterization Proceedings of the National Academy of Sciences of the United States of America. ,vol. 76, pp. 640- 644 ,(1979) , 10.1073/PNAS.76.2.640
S. Maeda, R. McCandliss, M. Gross, A. Sloma, P. C. Familletti, J. M. Tabor, M. Evinger, W. P. Levy, S. Pestka, Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 77, pp. 7010- 7013 ,(1980) , 10.1073/PNAS.77.12.7010
Ronald B. Herberman, John R. Ortaldo, Julie Y. Djeu, Howard T. Holden, James Jett, Nicholas P. Lang, Menachem Rubinstein, Sidney Pestka, Role of interferon in regulation of cytotoxicity by natural killer cells and macrophages. Annals of the New York Academy of Sciences. ,vol. 350, pp. 63- 71 ,(1980) , 10.1111/J.1749-6632.1980.TB20608.X
M. Masucci, R Szigeti, E Klein, G Klein, J Gruest, L Montagnier, H Taira, A Hall, S Nagata, C Weissmann, Effect of interferon-alpha 1 from E. coli on some cell functions. Science. ,vol. 209, pp. 1431- 1435 ,(1980) , 10.1126/SCIENCE.6158096
Shigekazu Nagata, Hideharu Taira, Alan Hall, Lorraine Johnsrud, Michel Streuli, Josef Ecsödi, Werner Boll, Kari Cantell, Charles Weissmann, Synthesis in E. Coli of a Polypeptide With Human Leukocyte Interferon Activity Nature. ,vol. 284, pp. 316- 320 ,(1980) , 10.1038/284316A0
David V. Goeddel, Elizabeth Yelverton, Axel Ullrich, Herbert L. Heyneker, Giuseppe Miozzari, William Holmes, Peter H. Seeburg, Thomas Dull, Laurie May, Nowell Stebbing, Roberto Crea, Shuichiro Maeda, Russell McCandliss, Alan Sloma, John M. Tabor, Mitchell Gross, Phillip C. Familletti, Sidney Pestka, Human leukocyte interferon produced by E. coli is biologically active Nature. ,vol. 287, pp. 411- 416 ,(1980) , 10.1038/287411A0
W. P. Levy, J. Shively, M. Rubinstein, U. Del Valle, S. Pestka, Amino-terminal amino acid sequence of human leukocyte interferon Proceedings of the National Academy of Sciences of the United States of America. ,vol. 77, pp. 5102- 5104 ,(1980) , 10.1073/PNAS.77.9.5102