Pulmonary Vascular Remodeling Correlates with Lung Eggs and Cytokines in Murine Schistosomiasis
作者： Alexi Crosby , Frances M Jones , Mark Southwood , Susan Stewart , Ralph Schermuly
DOI: 10.1164/RCCM.200903-0355OC
关键词:
摘要: Rationale: Schistosomiasis is considered to be the most common worldwide cause of pulmonary hypertension. At present there no well-characterized animal model study pathobiology this important condition.Objectives: To develop a mouse schistosomiasis, characterize extent vascular remodeling, and determine potential role inflammatory cytokines.Methods: Mice (C57/Bl6) were infected transcutaneously with high dose (∼75–100 cercariae) or low (∼30 Schistosoma mansoni, development lung liver pathology was studied in subacute (high-dose) chronic (low-dose) settings.Measurements Main Results: In setting, mice showed few eggs lungs evidence remodeling. contrast, chronically animals had much greater egg burden developed marked remodeling accompanied by perivascular inflammation from 12 weeks onwards. addition, we observed pres...
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