A common ancestor for human placental 17β‐hydroxysteroid dehydrogenase, Streptomyces coelicolor actIII protein, and Drosophila melanogaster alcohol dehydrogenase

摘要: A computer-based comparison of the amino acid sequences human placental 17 beta-hydroxysteroid dehydrogenase and Streptomyces coelicolor actIII protein, which is important in synthesis antibiotic actinorhodin, gives an alignment score 12.15 standard deviations higher than that 1000 comparisons randomized these proteins. The probability getting this by chance 3 x 10(-34). Comparison protein with Drosophila melanogaster alcohol yields a 10.3 (P = 3.5 10(-25)). Based on similarities, we propose dehydrogenase, are derived from common ancestor.