Cinnamic Derivatives in Tuberculosis

摘要: Tuberculosis (TB) is a threat to worldwide public health, mainly caused by Mycobacterium tuberculosis (M.tb.) bacteria species. Despite the availability of effective treatment, responsible for more than three million deaths annually worldwide. The high susceptibility human immunodeficiency virus-infected persons disease (Nunn et al., 2005), emergence multi-drug-resistant (MDR-TB) strains (Rastogi 1992, Kochi 1993; Bloch 1994) and extensively drug-resistant (XDR-TB) ones have brought this infectious into focus urgent scientific interest. For reason, there growing need urgency discover new classes chemical compounds acting with different mechanisms from those currently used. Cinnamic acid (1; Fig. 1) derivatives century-old history as antituberculosis agents. example, gradual improvement was observed when TB-patients were treated cinnamic (1) prepared storax (Warbasse, 1894). Furthermore, in 1920s, ethylcinnamate (2) (Jacobson, 1919), sodium cinnamate (3) (Corper 1920) benzylcinnamate (4) (Gainsborough, 1928) reported be efficacious treatment TB (Fig. 1). Nevertheless, we feel that class molecules remained underutilized until recent years. Particularly last two decades, has been huge attention towards various natural unnatural their efficacy. This chapter provides comprehensive literature compilation concerning synthesis so potency acid, cinnamaldehyde chalcone derivatives. We envisage our effort contributes much needed timely addition medicinal research.