To Open Up New Vistas in Basic and Preclinical Addiction Research

摘要: This is a personal perspective on some of the major achievements in addiction research and especially an attempt to point out most important future challenges basic preclinical this field. Given that addictive behavior result very complex “drug × gene environment” interaction, which has be even seen life-span perspective, new genetic approaches will discussed. In particular, convergent translational genomics are proposed integrate information from animal models (e.g., by means microarrary analysis) with alcoholics or drug addicts genome-wide association studies). novel tool help enhance explanatory power findings essential define profiles drive vulnerability develop behavior. Next interaction primary targets receptors) within brain context concept “agonist-directed trafficking receptor stimulus” introduced for key understand consequences drug/receptor interactions subsequent signalling transduction. New concepts also discussed regard drug-induced synaptic plasticity. Alterations level can modulate neuronal network activity studied multi-electrode recording ultra high-field imaging small rodents. A systems biology approach then helpful data sets obtained genetic, molecular, synaptic, order The knowledge derives such utmost importance improvement treatment situation. One appealing treat alcoholics, smokers, illicit users may disruption reconsolidation alcohol- drug-related memories.