NADH oxidase activity of indoleamine 2,3-dioxygenase.
作者： Federico I. Rosell , Hsin H. Kuo , A. Grant Mauk
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摘要: The heme enzyme indoleamine 2,3-dioxygenase (IDO) was found to oxidize NADH under aerobic conditions in the absence of other enzymes or reactants. This reaction led formation dioxygen adduct IDO and supported oxidation Trp N-formylkynurenine. Formation were accelerated by addition small amounts hydrogen peroxide, both processes inhibited presence either superoxide dismutase catalase. Anaerobic with proceeded only a mediator (e.g. methylene blue) resulted ferrous form enzyme. We propose that trace peroxide previously proposed occur solutions as well solid activate lead reactive
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