Diagnosis and treatment of bacteremia and endocarditis due to Staphylococcus aureus. A clinical guideline from the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC)

摘要: Both bacteremia and infective endocarditis caused by Staphylococcus aureus are common severe diseases. The prognosis may darken not infrequently, especially in the presence of intracardiac devices or methicillin-resistance. Indeed, optimization antimicrobial therapy is a key step outcome these infections. high rates treatment failure increasing interest influence vancomycin susceptibility infections both methicillin-susceptible -resistant isolates has led to research novel therapeutic schemes. Specifically, raised recent years on new antimicrobials with activity against methicillin-resistant staphylococci been also extended susceptible strains, which still carry most important burden infection. Recent clinical experimental focused combinations antimicrobials, their indication role being debatable. Also, impact an appropriate empirical acquired relevance years. Finally, it noteworthy implementation systematic bundle measures for improving outcome. aim this guideline provide ensemble recommendations order improve S. aureus, accordance latest evidence published.