In vitro immunoregulatory effects of lithium in healthy volunteers.

摘要: Rationale: There is now some evidence that major depression associated with activation of the inflammatory response system (IRS). Lithium effective in treatment and prophylaxis shows significant immunoregulatory functions. Objective: The aims present study were to examine vitro effects lithium on unstimulated lipolysaccharide (LPS) + phytohemagglutinin (PHA)-induced production proinflammatory cytokines, such as interleukin-6 (IL-6), IL-8, tumor necrosis factor-α (TNFα) interferon-γ (IFNγ), negative cytokines or proteins, IL-10 IL-1 receptor antagonist (IL-1RA). Methods: carbonate at low (10−4 M 10−5 M) therapeutic (10−3 concentrations above IL-1RA examined nine healthy volunteers whole blood supernatant cultured for 72 h. Results: presence LPS+PHA significantly increased stimulated IFNγ, TNFα, IL-10. IL-8 Conclusions: results suggest has by increasing both (IFNγ, TNFα IL-8) proteins (IL-10 IL-1RA).