Peptides as Targets and Carriers

摘要: The discovery of diverse neurohormonal and other biologically active peptides has increased interest in exploiting peptide mimetics as therapeutic drugs.1–4 high potency, local synthesis/release rapid in-activation natural can cause particular problems designing synthetic drug molecules that are both selective have reasonable duration action. Selective targeting is usually achieved by specific agonist/antagonist activity for a cell surface receptor or interaction with an enzyme site on peptidase, which turn involved either activating deactivating peptide. Synthetic also utility facilitating the uptake into target tissues permease specificities some cases tissue localization peptidases. These mechanisms will be discussed examples carrier targeted receptors. Particular comment will, however, made pharmacokinetic encountered drugs route administration, intestinal absorption, metabolic stability, distribution renal vs. biliary excretion.