Differential subcellular localization of Ror tyrosine kinase receptors in cultured astrocytes.
作者： Sabrina Paganoni , Kelsi L. Anderson , Adriana Ferreira
DOI: 10.1002/GLIA.20023
关键词:
摘要: Ror1 and Ror2 belong to a family of tyrosine kinase receptors that are highly conserved among species. They expressed throughout the organism, including central nervous system. In present study, we analyzed expression subcellular localization in astrocytes by means reverse transcription-polymerase chain reaction, Western blot analysis, immunocytochemistry. Our results indicated both readily detectable cultured astrocytes. also showed associated with different components cytoskeleton. While co-localized F-actin along stress fibers, partially microtubules. addition, our suggest undergo posttranslational modifications is glycosylated these cells. contrast, no glycosylation was detected Ror2. Taken together, distinct roles for © 2004 Wiley-Liss, Inc.
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