Effects of intravenous exenatide in type 2 diabetic patients with congestive heart failure: a double-blind, randomised controlled clinical trial of efficacy and safety

作者: D. Nathanson , B. Ullman , U. Löfström , A. Hedman , M. Frick

DOI: 10.1007/S00125-011-2440-X

关键词:

摘要: Aims/hypothesis The aim of this study was to determine whether exenatide improves haemodynamic function in patients with type 2 diabetes congestive heart failure (CHF).

参考文章(39)
C. Mark B. Edwards, Sarah A. Stanley, Rachel Davis, Audrey E. Brynes, Gary S. Frost, Leighton J. Seal, Mohammad A. Ghatei, Stephen R. Bloom, Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers American Journal of Physiology-endocrinology and Metabolism. ,vol. 281, ,(2001) , 10.1152/AJPENDO.2001.281.1.E155
S M Gardiner, J E March, P A Kemp, T Bennett, Autonomic nervous system‐dependent and ‐independent cardiovascular effects of exendin‐4 infusion in conscious rats British Journal of Pharmacology. ,vol. 154, pp. 60- 71 ,(2008) , 10.1038/BJP.2008.75
Lazaros A. Nikolaidis, Sunil Mankad, George G. Sokos, Glen Miske, Ankur Shah, Dariush Elahi, Richard P. Shannon, Effects of Glucagon-Like Peptide-1 in Patients With Acute Myocardial Infarction and Left Ventricular Dysfunction After Successful Reperfusion Circulation. ,vol. 109, pp. 962- 965 ,(2004) , 10.1161/01.CIR.0000120505.91348.58
C. Cabou, G. Campistron, N. Marsollier, C. Leloup, C. Cruciani-Guglielmacci, L. Penicaud, D. J. Drucker, C. Magnan, R. Burcelin, Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity. Diabetes. ,vol. 57, pp. 2577- 2587 ,(2008) , 10.2337/DB08-0121
Arpita Kalla Vyas, Kai-Chien Yang, Dennis Woo, Anatoly Tzekov, Attila Kovacs, Patrick Y. Jay, Paul W. Hruz, Exenatide Improves Glucose Homeostasis and Prolongs Survival in a Murine Model of Dilated Cardiomyopathy PLoS ONE. ,vol. 6, pp. e17178- ,(2011) , 10.1371/JOURNAL.PONE.0017178
Ö. Erdogdu, D. Nathanson, Å. Sjöholm, T. Nyström, Q. Zhang, Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS-, PKA- and PI3K/Akt-dependent pathways and requires GLP-1 receptor Molecular and Cellular Endocrinology. ,vol. 325, pp. 26- 35 ,(2010) , 10.1016/J.MCE.2010.04.022
Lionel H. Opie, Juhani Knuuti, The Adrenergic-Fatty Acid Load in Heart Failure Journal of the American College of Cardiology. ,vol. 54, pp. 1637- 1646 ,(2009) , 10.1016/J.JACC.2009.07.024
Kiwon Ban, M. Hossein Noyan-Ashraf, Judith Hoefer, Steffen-Sebastian Bolz, Daniel J. Drucker, Mansoor Husain, Cardioprotective and Vasodilatory Actions of Glucagon-Like Peptide 1 Receptor Are Mediated Through Both Glucagon-Like Peptide 1 Receptor–Dependent and –Independent Pathways Circulation. ,vol. 117, pp. 2340- 2350 ,(2008) , 10.1161/CIRCULATIONAHA.107.739938
Robert Gros, Xiaomang You, Laurie L. Baggio, M. Golam Kabir, Al Muktafi Sadi, Imran N. Mungrue, Thomas G. Parker, Qingling Huang, Daniel J. Drucker, Mansoor Husain, Cardiac Function in Mice Lacking the Glucagon-Like Peptide-1 Receptor Endocrinology. ,vol. 144, pp. 2242- 2252 ,(2003) , 10.1210/EN.2003-0007
Loek van Heerebeek, Nazha Hamdani, M. Louis Handoko, Ines Falcao-Pires, René J. Musters, Koba Kupreishvili, Alexander J.J. Ijsselmuiden, Casper G. Schalkwijk, Jean G.F. Bronzwaer, Michaela Diamant, Attila Borbély, Jolanda van der Velden, Ger J.M. Stienen, Gerrit J. Laarman, Hans W.M. Niessen, Walter J. Paulus, Diastolic Stiffness of the Failing Diabetic Heart Importance of Fibrosis, Advanced Glycation End Products, and Myocyte Resting Tension Circulation. ,vol. 117, pp. 43- 51 ,(2008) , 10.1161/CIRCULATIONAHA.107.728550