Effect of stress on the voluntary intake of a sweetened ethanol solution in pair-housed adolescent and adult rats.

摘要: Background: Data regarding the effects of stressors on ethanol intake are mixed. Previous experiments reporting greater voluntary in adolescent than adult rats have examined isolate-housed animals. Given that stress isolate housing may differ ontogenetically as well confound interpretation other stressor effects, present study stressor/ethanol interactions among pair-housed and rats. Methods: Sprague-Dawley male were implanted with identification tags allowed individual monitoring homecage water either a 10% (v/v) solution containing 0.1% (w/v) saccharin or alone over 14-day access period. Animals given zero, one, eight daily 15-min footshock sessions, shock-induced freezing pre-, post-, recovery corticosterone levels determined first last exposure days. After period, withdrawal was assessed plus maze, tolerance to ethanol-induced loss righting reflex examined. Results: Nonstressed adolescents drank considerably more sweetened did adults, chronic suppressing this consumption. Ethanol disrupted within-session adaptation terms behavior, although no such disruption evident at age when indexed hormonally. Despite relatively high intakes (up 6 g/kg/day adolescents), evidence for withdrawal-associated anxiogenesis emerged. Evidence mixed and, extent it present, metabolic nature. Conclusions: Previous reports heightened not function but Adolescents sensitive ethanol/stress elevated selectively by stress, stress-induced adults. Likewise, behavioral