Impact on bulk 15N natural isotopic abundance in hair of kidney function in type 2 diabetic nephropathy

摘要: summary Background and aims: Nephropathy is a serious long-term complication in type 2 diabetic patients. Few data are available about nitrogen metabolism nephropathy. Bulk 15 N natural isotopic abundance (NIA) hair has been shown modified different pathologies with altered protein metabolism. We have compared bulk NIA proteins patients to look for differences between groups or without Methods: Case were high urinary albumin concentrations (� 20 mg/L 30 mg/24 h on two of three urine collections) and/or an estimated glomerular filtration rate (eGFR) below 60 mL min � 1 1.73 m , according the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. Control subjects same geographical origin diabetes, normo-albuminuria eGFR above . The NN IA values measured by isotope ratio measurement mass spectrometry coupled elemental analyzer. Results: Thirty-three nephropathy group 31 control included. mean age participants was 69 ± 8 years, duration diabetes 22 years. 8.9 0.7‰ 9.0 0.5‰ (p ¼ 0.41). Positive correlations found < 0.01) urea concentration 0.01), negative correlation albumin-to-creatinine 0.001). Conclusions: