Genetics and Biosynthesis of Lipid A

作者: Christopher M. Stead , Aaron C. Pride , M. Stephen Trent

DOI: 10.1007/978-3-7091-0733-1_6

关键词:

摘要: The defining feature of Gram-negative bacteria is the presence an outer membrane, which comprises outermost surface cell envelope and is, therefore, in constant contact with surrounding environment. membrane unique as compared to most biological membranes that it asymmetric bilayer composed a phospholipid inner leaflet lipopolysaccharide (LPS) opposed symmetrical (Fig. 6.1). LPS confers properties including efficient permeability barrier affords additional protection from their

参考文章(156)
K Radika, C R Raetz, Purification and properties of lipid A disaccharide synthase of Escherichia coli. Journal of Biological Chemistry. ,vol. 263, pp. 14859- 14867 ,(1988) , 10.1016/S0021-9258(18)68118-9
T.M. Kelly, S.A. Stachula, C.R. Raetz, M.S. Anderson, The firA gene of Escherichia coli encodes UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase. The third step of endotoxin biosynthesis. Journal of Biological Chemistry. ,vol. 268, pp. 19866- 19874 ,(1993) , 10.1016/S0021-9258(19)36593-7
Christopher M. Stead, Jinshi Zhao, Christian R. H. Raetz, M. Stephen Trent, Removal of the outer Kdo from Helicobacter pylori lipopolysaccharide and its impact on the bacterial surface Molecular Microbiology. ,vol. 78, pp. 837- 852 ,(2010) , 10.1111/J.1365-2958.2010.07304.X
R C Goldman, C C Doran, S K Kadam, J O Capobianco, Lipid A precursor from Pseudomonas aeruginosa is completely acylated prior to addition of 3-deoxy-D-manno-octulosonate. Journal of Biological Chemistry. ,vol. 263, pp. 5217- 5223 ,(1988) , 10.1016/S0021-9258(18)60702-1
M.S. Anderson, H.G. Bull, S.M. Galloway, T.M. Kelly, S Mohan, K Radika, C.R. Raetz, UDP-N-acetylglucosamine acyltransferase of Escherichia coli. The first step of endotoxin biosynthesis is thermodynamically unfavorable. Journal of Biological Chemistry. ,vol. 268, pp. 19858- 19865 ,(1993) , 10.1016/S0021-9258(19)36592-5
K A Brozek, K Hosaka, A D Robertson, C R Raetz, Biosynthesis of lipopolysaccharide in Escherichia coli. Cytoplasmic enzymes that attach 3-deoxy-D-manno-octulosonic acid to lipid A. Journal of Biological Chemistry. ,vol. 264, pp. 6956- 6966 ,(1989) , 10.1016/S0021-9258(18)83524-4