Reconstructed human epidermis composed of keratinocytes, melanocytes and Langerhans cells
作者： M. Régnier , A. Patwardhan , A. Scheynius , R. Schmidt
DOI: 10.1007/BF02518889
关键词:
摘要: In addition to their basic biological interest, models of reconstructed epidermis provide useful tools for in vitro assessment the toxicology and efficacy new chemicals drugs. The fact that majority these are composed only keratinocytes has excluded use fields skin pigmentation immunology. After successful introduction functional melanocytes into epidermal reconstruct, integration Langerhans cells remains an important challenge, particularly since after isolation from human epidermis, cannot be subcultured do not integrate reconstructing epidermis. authors show cord blood derived CD34+ progenitors isolated peripheral give rise residential when co-seeded with normal keratinocytes.
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sci-hub.se 参考文章(22)
SANDRINE BESSOU, JEAN-ETIENNE SURLEVE-BAZEILLE, EVELYNE SORBIER, ALAIN TAIEB, Ex Vivo Reconstruction of the Epidermis With Melanocytes and the Influence of UVB Pigment Cell Research. ,vol. 8, pp. 241- 249 ,(1995) , 10.1111/J.1600-0749.1995.TB00670.X
G. ROWDEN, M. G. LEWIS, A. K. SULLIVAN, Ia antigen expression on human epidermal Langerhans cells. Nature. ,vol. 268, pp. 247- 248 ,(1977) , 10.1038/268247A0
C Caux, B Vanbervliet, C Massacrier, C Dezutter-Dambuyant, B de Saint-Vis, C Jacquet, K Yoneda, S Imamura, D Schmitt, J Banchereau, CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha. Journal of Experimental Medicine. ,vol. 184, pp. 695- 706 ,(1996) , 10.1084/JEM.184.2.695
Herlyn M, Murphy Gf, Whitaker D, Mancianti Ml, Valyi-Nagy It, Phenotypes and interactions of human melanocytes and keratinocytes in an epidermal reconstruction model. Laboratory Investigation. ,vol. 62, pp. 314- 324 ,(1990)
D Strunk, K Rappersberger, C Egger, H Strobl, E Kromer, A Elbe, D Maurer, G Stingl, Generation of human dendritic cells/Langerhans cells from circulating CD34+ hematopoietic progenitor cells Blood. ,vol. 87, pp. 1292- 1302 ,(1996) , 10.1182/BLOOD.V87.4.1292.BLOODJOURNAL8741292
Moellmann G, Lerner Ab, Olsson Mj, Juhlin L, Vitiligo : repigmentation with cultured melanocytes after cryostorage Acta Dermato-venereologica. ,vol. 74, pp. 226- 228 ,(1994) , 10.2340/0001555574226228
Reconstructed Human Skin S. Karger AG. ,(1990) , 10.1159/ISBN.978-3-318-01507-2
Heidrun Moll, The Immune Functions of Epidermal Langerhans Cells ,(2013)
M L Kripke, C Bucana, C G Munn, J M Tang, A Jeevan, Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization. Journal of Immunology. ,vol. 145, pp. 2833- 2838 ,(1990)
G. Rowden, P. Colp, S. Dean, F. Auger, C. Lopes Valle, Comparative epidermal Langerhans cell migration studies in epidermal and epidermal/dermal equivalent grafts. Journal of Investigative Dermatology. ,vol. 99, pp. 59- 61 ,(1992) , 10.1111/1523-1747.EP12669006