The relative bioavailability of levonorgestrel and ethinyl estradiol administered as a low-dose combination oral contraceptive.
作者： Uwe Goebelsmann , David Hoffman , Soong Chiang , Theodore Woutersz
DOI: 10.1016/0010-7824(86)90087-9
关键词:
摘要: The relative bioavailability of levonorgestrel (LNG) and ethinyl estradiol (EE) administered concomitantly both as an oral tablet a solution was assessed in randomized two-period crossover study 24 healthy women. Serum concentrations were monitored for 96 h after each administration. (Fr) LNG the with respect to 107%; thus two formulations bioequivalent LNG. EE, however, significantly lower (Fr 83%) compared solution. This difference may have been due either decreased absorption or enhanced presystemic elimination EE from formulation.
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sci-hub.se 参考文章(15)
Arne Victor, Erik Weiner, Elof D. B. Johansson, Relation between sex hormone binding globulin and D-norgestrel levels in plasma. European Journal of Endocrinology. ,vol. 86, pp. 430- 436 ,(1977) , 10.1530/ACTA.0.0860430
D. J. CUTLER, Theory of the mean absorption time, an adjunct to conventional bioavailability studies. Journal of Pharmacy and Pharmacology. ,vol. 30, pp. 476- 478 ,(2011) , 10.1111/J.2042-7158.1978.TB13296.X
Jerold Newburger, Joseph W. Goldzieher, Pharmacokinetics of ethynyl estradiol: A current view Contraception. ,vol. 32, pp. 33- 44 ,(1985) , 10.1016/0010-7824(85)90114-3
Frank Z. Stanczyk, Masahiko Hiroi, Uwe Goebelsmann, Paul F. Brenner, Mary E. Lumkin, Daniel R. Mishell, Radioimmunoassay of serum d-norgestrel in women following oral and intravaginal administration Contraception. ,vol. 12, pp. 279- 298 ,(1975) , 10.1016/0010-7824(75)90088-8
Frank Z. Stanczyk, Judith A. Gale, Uwe Goebelsmann, Clint Nerenberg, Shaikh Matin, RADIOIMMUNOASSAY OF PLASMA ETHINYLESTRADIOL IN THE PRESENCE OF CIRCULATING NORETHINDRONE Contraception. ,vol. 22, pp. 457- 470 ,(1980) , 10.1016/0010-7824(80)90099-2
Staffan Nilsson, Karl-Gösta Nygren, Elof D.B. Johansson, Ethinyl estradiol in human milk and plasma after oral administration Contraception. ,vol. 17, pp. 131- 139 ,(1978) , 10.1016/0010-7824(78)90069-0
M. Hümpel, H. Wendt, G. Pommerenke, Chr. Weiβ, U. Speck, Investigations of pharmacokinetics of levonorgestrel to specific consideration of a possible first-pass effect in women. Contraception. ,vol. 17, pp. 207- 220 ,(1978) , 10.1016/0010-7824(78)90012-4
Lorraine Dennerstein, Ken Fotherby, Graham D. Burrows, Betty Laby, Carl Wood, Plasma levels of ethinyl oestradiol and norgestrel during hormone replacement therapy Maturitas. ,vol. 2, pp. 147- 154 ,(1980) , 10.1016/0378-5122(80)90049-3
DAVID C. ANDERSON, SEX-HORMONE-BINDING GLOBULIN Clinical Endocrinology. ,vol. 3, pp. 69- 96 ,(1974) , 10.1111/J.1365-2265.1974.TB03298.X
D.J. Back, A.M. Breckenridge, Francesca E. Crawford, M. MacIver, M.L'e. Orme, P.H. Rowe, Margaret J. Watts, An investigation of the pharmacokinetics of ethynylestsadiol in women using badioimmunoassay Contraception. ,vol. 20, pp. 263- 273 ,(1979) , 10.1016/0010-7824(79)90098-2