CTD kinase I is involved in RNA polymerase I transcription

摘要: RNA polymerase II carboxy terminal domain (CTD) kinases are key elements in the control of mRNA synthesis. Yeast CTD kinase I (CTDK-I), is a non-essential complex involved regulation synthesis at level transcription elongation, pre-mRNA 3' formation and nuclear export. Here, we report that CTDK-I also ribosomal We show localized part nucleolus. In its absence, nucleolar structure affected. vitro experiments an impairment Pol machinery. Remarkably, co-precipitates from cellular extracts with Ctk1, subunit complex. analysis further demonstrates direct interaction between Ctk1. The results suggest might participate distinct transcriptional machineries, thus playing role adaptation global response to growth signalling.