Genetic polymorphisms of vitamin D metabolism genes and serum level of vitamin D in colorectal cancer.
作者： Veronica Marques Vidigal , Pedro Nazareth Aguiar , Tiago Donizetti Silva , Juliana de Oliveira , Célia Aparecida Marques Pimenta
DOI: 10.5301/IJBM.5000282
关键词:
摘要: BACKGROUND The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 CYP24A1 can influence serum levels. aim this study was to investigate relationship polymorphisms VDR (ApaI BsmI), CYP27B1 with levels in both forms, 25(OH)D3 (circulating form) 1,25(OH)2D3 (active form), colorectal cancer (CRC) patients. METHODS One hundred fifty-two CRC patients 321 controls were included. DNA extracted from peripheral blood. Polymorphisms BsmI ApaI identified PCR-RFLP. Those (rs6013897, rs158552 rs17217119) (rs10877012) determined gene sequencing. RESULTS median circulating not different between controls; however, percentage those deficient higher cancer. active form VDR, polymorphic genotypes had no on D. correlation forms lower among CRC, regardless presence or absence any genetic polymorphism. mean genotype variants Apa1 Bsm1. CONCLUSIONS a frequence insufficient concentration These BsmI, CYP27B1. Polymorphic cause
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