Sorghum [Sorghum bicolor (L.) Moench] leaf sheath dye protects against cisplatin-induced hepatotoxicity and oxidative stress in rats.
作者： Adedayo O. Ademiluyi , Ganiyu Oboh , Oluwaseun J. Agbebi , Aline A. Boligon , Margareth L. Athayde
关键词:
摘要: Abstract This study sought to determine the protective effect of dietary inclusion sorghum leaf sheath dye on cisplatin-induced hepatotoxicity and oxidative stress in rats. Adult male rats were randomly divided into four groups with six animals each group. Groups I II fed a basal diet, while III IV diets containing 0.5% 1% dye, respectively, for 20 days before cisplatin administration. Hepatotoxicity was induced by single dose (7 mg/kg body weight, i.p.), experiment terminated at 3 after injection. The liver plasma studied antioxidant capacity. Cisplatin caused significant (P<.05) alteration enzymatic (catalase, glutathione-S-transferase [GST], superoxide dismutase [SOD]) nonenzymatic (glutathione [GSH] vitamin C) indices concomitant increase malondialdehyde (MDA) content; however, there re...
sci-hub.se 参考文章(49)
Neife Aparecida Guinaim dos Santos, Nádia Maria Martins, Carlos Curti, Maria de Lourdes Pires Bianchi, Antonio Cardozo dos Santos, Dimethylthiourea protects against mitochondrial oxidative damage induced by cisplatin in liver of rats. Chemico-Biological Interactions. ,vol. 170, pp. 177- 186 ,(2007) , 10.1016/J.CBI.2007.07.014
Joseph M. Awika, Lloyd W. Rooney, Sorghum phytochemicals and their potential impact on human health. Phytochemistry. ,vol. 65, pp. 1199- 1221 ,(2004) , 10.1016/J.PHYTOCHEM.2004.04.001
Hideo Kamei, Takasi Kojima, Makoto Hasegawa, Taturou Koide, Tessei Umeda, Takao Yukawa, Keisuke Terabe, Suppression of Tumor Cell Growth by Anthocyanins In Vitro Cancer Investigation. ,vol. 13, pp. 590- 594 ,(1995) , 10.3109/07357909509024927
Evans Mutegi, Fabrice Sagnard, Moses Muraya, Ben Kanyenji, Bernard Rono, Caroline Mwongera, Charles Marangu, Joseph Kamau, Heiko Parzies, Santie de Villiers, Kassa Semagn, Pierre Sibiry Traoré, Maryke Labuschagne, Ecogeographical distribution of wild, weedy and cultivated Sorghum bicolor (L.) Moench in Kenya: implications for conservation and crop-to-wild gene flow Genetic Resources and Crop Evolution. ,vol. 57, pp. 243- 253 ,(2010) , 10.1007/S10722-009-9466-7
T.A. Ajith, S. Usha, V. Nivitha, Ascorbic acid and α-tocopherol protect anticancer drug cisplatin induced nephrotoxicity in mice : a comparative study Clinica Chimica Acta. ,vol. 375, pp. 82- 86 ,(2007) , 10.1016/J.CCA.2006.06.011
George L. Ellman, Tissue sulfhydryl groups Archives of Biochemistry and Biophysics. ,vol. 82, pp. 70- 77 ,(1959) , 10.1016/0003-9861(59)90090-6
Takanori Tsuda, Fumihiko Horio, Toshihiko Osawa, The role of anthocyanins as an antioxidant under oxidative stress in rats. Biofactors. ,vol. 13, pp. 133- 139 ,(2000) , 10.1002/BIOF.5520130122
Kulbhushan Tikoo, Deepak Kumar Bhatt, Anil Bhanudas Gaikwad, Vikram Sharma, Dhiraj G. Kabra, Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats. FEBS Letters. ,vol. 581, pp. 2027- 2035 ,(2007) , 10.1016/J.FEBSLET.2007.04.036
Heba Hosny Mansour, Hafez Farouk Hafez, Nadia Mohamed Fahmy, Silymarin modulates Cisplatin-induced oxidative stress and hepatotoxicity in rats. Journal of Biochemistry and Molecular Biology. ,vol. 39, pp. 656- 661 ,(2006) , 10.5483/BMBREP.2006.39.6.656
Laura Trapani, Regulation and deregulation of cholesterol homeostasis: The liver as a metabolic “power station” World Journal of Hepatology. ,vol. 4, pp. 184- 190 ,(2012) , 10.4254/WJH.V4.I6.184