The Timing of Total Thyroidectomy in RET Gene Mutation Carriers Could Be Personalized and Safely Planned on the Basis of Serum Calcitonin: 18 Years Experience at One Single Center

摘要: Background: Medullary thyroid carcinoma (MTC) is a calcitonin (CT)-producing C-cell tumor. In hereditary cases, germline RET mutation found in 98% of families. Because MTC cured only if intrathyroidal, prophylactic thyroidectomy recommended the gene carrier (GC). Aims: The aim was to determine whether performed when stimulated CT becomes detectable as safe and identify serum cutoff able distinguish intrathyroidal from extrathyroidal MTC. Patients: Eighty-four GC were prospectively enrolled; 53 84 underwent total thyroidectomy, one refused surgery, 30 with normal basal under surveillance. follow-up ranged 2 18 yr. Results: operated on for elevated included 27 positive peak at screening four cases who became after 4 All them had no node metastases; all mean 7.5 Among those opera...