Dopamine and retinal function

摘要: This review summarizes the experimental evidence in support of dopamine's role as a chemical messenger for light adaptation. Dopamine is released by unique set amacrine cells and activates D1 D2 dopamine receptors distributed throughout retina. Multiple dopamine-dependent physiological mechanisms result an increased signal flow through cone circuits diminution rod circuits. also has multiple trophic roles retinal function related to circadian rhythmicity, cell survival eye growth. In reciprocal way, health dopaminergic neurons depends on their receiving light-driven synaptic inputs. appear early development, become functional advance animal's onset vision begin die aging animals. Some diseases affecting photoreceptor diminish day/night differences release turnover. A reduction dopamine, occurs Parkinsonian patients, results reduced visual contrast sensitivity.