Insulin resistance pathogenesis in visceral fat and gut organisms

摘要: Epidemiological work has shown that visceral adiposity is strongly related to metabolic disorders including insulin resistance. What regulates fat deposition and why it so metabolically deleterious remains largely unclear. Recent data suggest the gastrointestinal tract may be a central player in development of accumulation syndrome. An impaired gut barrier function, as consequence inflammation and/or altered microbiota composition, increases leak microbial molecules their metabolites adjacent mesenteric resulting hypertrophy depot. Subsequently, increased efflux fatty acids pro-inflammatory factors portal vein leads liver dysfunction systemic